Wild type and H43Y variant of human TRIM5 alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro

作者：Nakayama Emi E; Carpentier Wassila; Costagliola Dominique; Shioda Tatsuo^*; Iwamoto Aikichi; Debre Patrice; Yoshimura Kazuhisa; Autran Brigitte; Matsushita Shuzo; Theodorou Ioannis

来源：Immunogenetics, 2007, 59(6): 511-515.

DOI：10.1007/s00251-007-0217-7

• TRIM5 alpha
• H43Y
• RING domain
• polymorphism
• HIV-1 disease progression
• anti-HIV-1 activity

Polymorphisms in human genes have been shown to affect the rate of disease progression to acquired immune deficiency syndrome in human immunodeficiency virus type 1 (HIV-1)-infected individuals. Recently, tripartite motif 5 alpha (TRIM5 alpha) was identified as a factor that confers resistance to HIV-1 infection in Old World monkey cells. Subsequently, Sawyer et al. (Curr Biol 16:95-100, 2006) reported a single nucleotide polymorphism (H43Y) in the human TRIM5 alpha gene and TRIM5 alpha protein with 43Y was found to lose its ability to restrict HIV-1. In the present study, we reevaluated effects of this allele on in vitro anti-HIV-1 activity as well as on HIV-1 disease progression in European and Asian cohorts of HIV-1-infected individuals. Our epidemiological and molecular biological findings clearly indicate H43Y has a very minor effect on anti-HIV-1 activity of TRIM5 alpha, suggesting that this allele is immaterial, at least in HIV-1-infected Europeans and Asians.

• 出版日期2007-6
• 单位河北医科大学