科研之友
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摘要
A new and practical method for the asymmetric synthesis of gamma-amino acids from beta,gamma-butenolides by an in situ esterification, condensation, and reduction in a one-pot procedure is described. This method is quite general for the preparation of both enantiomers of aryl or aliphatic gamma-amino acids in high yields. These gamma-amino-acid derivatives were also shown to be versatile synthetic intermediates for further transformations by their conversion to gamma-lactams, delta-amino alcohols, and hydrolysis products in high yields with no racernization.
- 出版日期2012-7-20
