Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives

作者：Dou Dengfeng; Alex Deepu; Du Bingfan; Tiew Kok Chuan; Aravapalli Sridhar; Mandadapu Sivakoteswara Rao; Calderone Richard; Groutas William C^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(19): 5782-5787.

DOI：10.1016/j.bmc.2011.08.029

• Antifungal agents
• Broad spectrum

A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.

• 出版日期2011-10-1