A new synthesis method and crystal structure of 2-phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol

作者：Gao Yong Guang; Mu Chu Chun; Li Xin Sheng^*; Xu Dong Cheng; Su Hong; Wen Yi Hang

来源：Chinese Journal of Structural Chemistry, 2008, 27(6): 663-666.

• pyridylalcohol
• synthesis
• crystal structure

The title compound 2-phenyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methano-8-quinolinol 1 has been synthesized by the oxidation of corresponding anion with O-2. The oxidation gave a convenient method for synthesizing pyridylalcohol. 1 in good yield. The suitable single crystals for X-ray diffraction were obtained by recrystallization from a mixture of solvents (ether and ethyl acetate). The configuration of C6 in the title compound is in R form and there are strong face-to-face offset pi-pi interactions between pyridine rings. Crystallographic data for 1: C18H19NO, M-r = 265.34, monoclinic, space group P2(1)/c with a = 13.4073(4), b = 10.2866(3), c = 10.5570(3) angstrom, beta = 108.413(2)degrees, V = 1381.43(7) angstrom(3), Z = 4, D-c = 1.276 g/cm(3) mu = 0.078 mm(-1), F(000) = 568, R = 0.0721 and wR = 0.2054 for 2241 observed reflections (I > 2 sigma(I)).

• 出版日期2008
• 单位浙江师范大学