Novel composites using hydrogel and BCP granules: Preclinical studies

作者：Daculsi G^*; Uzel A P; Goyenvalle E; Aguado E; Pilet P; Moreau F; Borget P; Baroth S

来源：Journal of the Australian Ceramic Society, 2011, 47(1): 60-63.

• bone regeneration
• biocompatibility
• reticulated hydrogel
• biphasic calcium phosphate putty

Calcium phosphate bioceramic granules associated with hydrosoluble polymers were developed as bone substitutes for various maxillofacial and orthopaedic applications. These resorbable bone substitute putties, support and regenerate bone tissue after implantation. The efficiency of these multiphasic materials is due to the osteogenic and osteoconductive properties of the microporous biphasic calcium phosphate bioceramic. The associated hydrosoluble polymers are considered as carriers in order to achieve the rheological properties of putty mouldable bone substitutes. In this study, 2 types of hydrosoluble polymers were tested. The first one is a thermo reversible polymer (polaxamer) and the second one is a reticulated hydrogel (polysaccharidic) obtain by e-beam irradiation. The 2 types of hydrogels were associated to microporous biphasic calcium phosphate (HA/TCP) bioceramics and implanted in goat vertebrae bodies. No foreign body reactions were observed in the two samples. This study demonstrates good handling of the two putties, good biocompatibility, high resorbability and bone ingrowth at the expense of the materials.

• 出版日期2011