An imbalanced OPG/TRAIL ratio is associated to severe acute myocardial infarction

作者：Secchiero Paola; Corallini Federica; Beltrami Antonio Paolo; Ceconi Claudio; Bonasia Vincenzo; Di Chiara Antonio; Ferrari Roberto; Zauli Giorgio^*

来源：Atherosclerosis, 2010, 210(1): 274-277.

DOI：10.1016/j.atherosclerosis.2009.11.005

• TRAIL
• OPG
• Acute myocardial infarction
• Heart failure

Background: This study was designed to evaluate the biological significance of simultaneous changes in the circulating levels of osteoprotegerin (OPG) and TNF-related apoptosis inducing ligand (TRAIL) in patients with coronary artery disease (CAD), and, in particular, with acute myocardial infarction (AMI).
Methods: Total levels of OPG and TRAIL were measured by ELISA in patients with AMI (n = 113), unstable angina (UA, n = 21) and healthy controls (n = 120).
Results: Since OPG was elevated during the acute phase (first 12-24-48 h) after AMI and in patients with UA with respect to healthy controls, while TRAIL was decreased in acute AMI patients, CAD patients were characterized by an increased OPG/TRAIL ratio. Moreover, the OPG/TRAIL ratio was significantly (p < 0.05) higher in the acute AMI patients who developed heart failure (HF) than in those who did not develop HF in the follow-up.
Conclusions: An impaired OPG/TRAIL ratio after AMI is related to a higher risk of HF.

• 出版日期2010-5