Anti-Tumor Activity of a Polysaccharide from Blueberry

作者：Sun, Xiyun; Liu, Ning; Wu, Zhaoxia; Feng, Ying; Meng, Xianjun^*

来源：Molecules, 2015, 20(3): 3841-3853.

DOI：10.3390/molecules20033841

• IMMUNOMODULATING ACTIVITIES
• GANODERMA-LUCIDUM
• PROTEIN COMPLEX
• IN-VITRO
• ANTIOXIDANT
• ENHANCEMENT
• IMMUNITY
• EXTRACT
• VIVO

Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg center dot kg(-1)center dot d(-1)) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-alpha, IFN-gamma, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.

• 出版日期2015-3
• 单位沈阳农业大学