科研之友
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摘要
In this manuscript, a novel approach to 3,4-dihydrocoumarins is presented. It utilizes the aminocatalytic, trienamine-mediated cycloaddition reaction between 2,4-dienals and ethyl coumarincarboxylates. The reaction is promoted by a bifunctional aminocatalyst bearing a hydrogen-bonding squaramide structural unit. As a consequence, the stereochemical outcome is governed through the double hydrogen-bonding interactions between the hydrogen-bonding moiety of the catalyst and the dienophile. The transformation of the obtained cycloadducts into 3,4-dihydrocoumarins bearing a bislactone structural motif is presented.
- 出版日期2016-9
