Acute intermittent porphyria: comorbidity and shared familial risks with schizophrenia and bipolar disorder in Sweden

作者:Cederlof Martin*; Bergen Sarah E; Larsson Henrik; Landen Mikael; Lichtenstein Paul
来源:The British Journal of Psychiatry, 2015, 207(6): 556-557.
DOI:10.1192/bjp.bp.114.157073

摘要

Acute intermittent porphyria (AIP) has been associated with schizophrenia in some studies, but prior research is limited by the absence of comparison populations. Here, we linked Swedish registers to examine the risk of schizophrenia and bipolar disorder in 717 individuals diagnosed with AIP and their first-degree relatives, compared with matched individuals without AIP and their first-degree relatives. Individuals with AIP had a fourfold increased risk of schizophrenia or bipolar disorder. Similarly, relatives of individuals with AIP had double the risk of schizophrenia or bipolar disorder, suggesting that these associations may be as a result of common genetic influences.

  • 出版日期2015-12