Diastereomeric Resolution of p-Chloromandelic Acid with (R)-Phenylethylamine

作者：He, Quan; Peng, Yang-Feng; Rohani, Sohrab^*

来源：Chirality, 2010, 22(1): 16-23.

DOI：10.1002/chir.20695

• p-chloromandelic acid
• phenylethylamine
• resolution
• diastereomeric salt
• crystal structure
• binary melting point phase diagram

The optical resolution of p-chloromandelic acid using (R)-alpha-phenylethylamine as resolving agent was presented. The effect of solvents, molar ratio of racemate to the resolving agent, filtration temperature as well as the amount of solvent on resolution was investigated by orthogonal experimentation. The binary melting point phase diagram and crystal structure analysis of diastereomeric salts rationalized the success of the resolution. Chirality 22:1.6-23, 2010.

• 出版日期2010-1
• 单位宁波工程学院; 华东理工大学