An efficient and green procedure for synthesis of rhodanine derivatives by aldol-thia-Michael protocol using aqueous diethylamine medium

作者:Barakat Assem*; Al Majid Abdullah M; Al Najjar Hany J; Mabkhot Yahia N; Ghabbour Hazem A; Fun Hoong Kun
来源:RSC Advances, 2014, 4(10): 4909-4916.
DOI:10.1039/c3ra46551a

摘要

A simple, economical, and green approach to the synthesis of rhodanine derivatives using a tandem aldol condensation-thia-Michael addition process in aqueous diethylamine medium was described. The experiment protocol features simple operations, and the products were isolated in high to excellent yields (82-96%). As spontaneous precipitation always occurs at the end of the process, this leads to easy separation of the products via a simple filtration.

  • 出版日期2014