Antiviral Triketone-Phloroglucinol-Monoterpene Adducts from Callistemon rigidus

作者:Cao, Jia-Qing; Wu, Yan; Zhong, Yuan-Lin; Li, Ni-Ping; Chen, Mu; Li, Man-Mei; Ye, Wen-Cai*; Wang, Lei*
来源:Chemistry and Biodiversity, 2018, 15(7): e1800172.
DOI:10.1002/cbdv.201800172

摘要

Callistrilones F - K (1 - 6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds 3 and 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV-1) with IC50 values of 10.00 +/- 2.50 and 12.50 +/- 1.30 m, respectively.