Tiotropium improves walking endurance in COPD

作者：Bedard M E; Brouillard C; Pepin V; Provencher S; Milot J; Lacasse Y; Leblanc P; Maltais F^*

来源：European Respiratory Journal, 2012, 39(2): 265-271.

DOI：10.1183/09031936.00059511

• Bronchodilation
• chronic obstructive pulmonary disease
• exercise
• shuttle walking test
• tiotropium
• walking

The primary objective of this study was to evaluate the effects of a 3-week treatment with tiotropium on walking capacity in chronic obstructive pulmonary disease (COPD). %26lt;br%26gt;After familiarisation with study procedures, 36 patients were randomised to receive tiotropium 18 mu g once daily or a matching placebo in a double-blind, parallel-group study. Pre- (trough) and 2-h post-dose pulmonary function was measured. An endurance shuttle walk was then completed. The same procedures were repeated after 3 weeks of treatment. Ventilatory parameters were monitored during exercise. %26lt;br%26gt;At 3 weeks, tiotropium significantly improved walking endurance time in comparison with placebo, with a mean +/- SD between-group difference of 128 +/- 141 s (p=0.017). At 3 weeks, trough values for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were significantly improved with tiotropium in comparison with placebo. The post-dose response to tiotropium was statistically superior to placebo after the first dose and after 3 weeks of treatment for FEV1, FVC and inspiratory capacity. Ventilation and tidal volume at the end of walking were significantly improved with tiotropium. %26lt;br%26gt;3 weeks of tiotropium resulted in a greater walking endurance in patients with COPD. Improvements in FEV1, maximal ventilation and tidal volume may contribute to this enhanced exercise capacity.

• 出版日期2012-2