Design of lactoferrin modified lipid nano-carriers for efficient brain-targeted delivery of nimodipine

作者：Zhao, Chaoyue; Zhang, Jiulong; Hu, Haiyang; Qiao, Mingxi; Chen, Dawei; Zhao, Xiuli^*; Yang, Chunrong^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2018, 92: 1031-1040.

DOI：10.1016/j.msec.2018.02.004

• Systematic evaluation
• Nanostructured lipid carries
• Nimodipine
• Lactoferrin
• Brain target

Blood-brain barrier (BBB) was the major obstacle for efficient delivery of therapeutic agents to brain tissue. To overcome this barrier, a novel lactoferrin modified long circulation nanostructured lipid carriers (Lf-NLC) was designed and synthesized for the efficient delivery of neuroprotective agent nimodipine (NMD) to brain tissue. NMD loaded Lf-NLC was optimized to exhibit a small and uniform particle size distribution and high loading content. More interestingly, Lf-NLC showed the excellent neuroprotective effect due to the efficient intracellular delivery NMD, in PC12 based stroke cell model induced by sodium nitroprusside (SNP). Cellular uptake assay indicated that Lf-NLC could be internalized into cytoplasm via Lf-receptor mediated endocytosis pathway. In vivo biodistribution assay demonstrated Lf-NLC could efficiently deliver therapeutic agent to brain tissue, indicating its promising application in brain delivery.

• 出版日期2018-11-1
• 单位佳木斯大学; 沈阳药科大学