Association between the C804A polymorphism in the TGF-beta gene and the risk of myocardial infarction: a meta-analysis

作者：Suo D W^*; Hu Q; Chen J; Sun Q H; Guo H

来源：Genetics and Molecular Research, 2015, 14(1): 1566-1579.

DOI：10.4238/2015.March.6.4

• Meta-analysis
• Myocardial infarction
• Polymorphism
• TNF-beta

Tumor necrosis factor-beta (TNF-beta) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-beta gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-beta C804A polymorphism to MI risk. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar databases to identify eligible studies published before November 1, 2013. We performed a meta-analysis of 9 case-control studies, which included a total of 19,404 MI patients and 13,684 healthy controls. Overall analysis suggested that the TNF-beta C804A polymorphism was associated with a significantly increased risk of MI. Stratified analysis based on ethnicity revealed a significant association in Asian populations, but not in Caucasian populations. In conclusion, this meta-analysis revealed that the TNF-beta C804A polymorphism may be associated with an increased risk of MI only in Asian populations. However, additional studies should be conducted to further confirm the association between TNF-beta C804A and MI risk.

• 出版日期2015
• 单位郑州大学