Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women

作者：Jeon Young Joo; Choi Yi Seul; Rah HyungChul; Kim Su Yeoun; Choi Dong Hee; Cha Sun Hee; Shin Ji Eun; Shim Sung Han; Lee Woo Sik^*; Kim Nam Keun

来源：Gene, 2012, 494(2): 168-173.

DOI：10.1016/j.gene.2011.12.026

• Genetic association
• MicroRNA (miRNA)
• Recurrent spontaneous abortion (RSA)
• Polymorphism

Aim: The aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA).
Methods: We conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss.
Results: RSA patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645-7.624).
Conclusion: miR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women.

• 出版日期2012-2-25