Hybrid Fluorinated and Hydrogenated Double-Chain Surfactants for Handling Membrane Proteins

作者:Legrand Frederic; Breyton Cecile; Guillet Pierre; Ebel Christine; Durand Gregory*
来源:Journal of Organic Chemistry, 2016, 81(2): 681-688.
DOI:10.1021/acs.joc.5b02137

摘要

Two hybrid fluorinated double-chain surfactants with a diglucosylated polar head were synthesized. The apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side chain. They were found to self-assemble into small micelles at low critical micellar concentrations, demonstrating that the short branch increases the overall hydrophobicity while keeping the length of the apolar domain short. They were both able to keep the membrane protein bacteriorhodopsin stable, one of them for at least 3 months.

  • 出版日期2016-1-15
  • 单位中国地震局