Nrf2 expression is associated with poor outcome in osteosarcoma

作者：Park Jae Young; Kim Youn Wha; Park Yong Koo^*

来源：Pathology, 2012, 44(7): 617-621.

DOI：10.1097/PAT.0b013e328359d54b

• Immunohistochemistry
• NF-E2-related factor 2
• osteosarcoma
• prognosis

Aims: NF-E2-related factor 2 (Nrf2) is involved in defence against oxidative stress in human cells. Nrf2 is over-expressed in many types of cancers suggesting that it plays a role in carcinogenesis and chemoresistance. We examined Nrf2 expression in osteosarcoma to determine its prognostic significance. %26lt;br%26gt;Methods: Nrf2 expression was assessed using immunohistochemistry in 58 specimens from patients with osteosarcoma. We investigated whether Nrf2 expression was associated with clinicopathological parameters. %26lt;br%26gt;Results: Nrf2 was positively expressed in 19 (32.8%) of 58 specimens. Nrf2 expression in osteosarcoma indicated a poor prognostic outcome (p = 0.0074), and correlated with worse disease-free survival (p = 0.0279). Nrf2 expression had a significant relationship with histological subtype (osteoblastic versus non-osteoblastic, p = 0.042); the non-osteoblastic subtype showed a higher rate of Nrf2 expression (50.0%) than the osteoblastic subtype (23.7%). Nrf2 expression showed no significant relationship with response to neoadjuvant chemotherapy (p = 0.115). Other clinicopathological parameters had no relationship with Nrf2 expression. %26lt;br%26gt;Conclusion: Increased expression of Nrf2 is associated with a poor outcome and disease-free survival in osteosarcoma. Our results suggest that Nrf2 is a possible marker of poor prognosis in osteosarcoma.

• 出版日期2012-12