A rapid, one-pot, four-component route to 2H-indazolo[2,1-b]phthalazine-triones

作者：Mosaddegh Elaheh^*; Hassankhani Asadollah

来源：Tetrahedron Letters, 2011, 52(4): 488-490.

DOI：10.1016/j.tetlet.2010.08.099

A new, efficient, and environmentally benign protocol for the one-pot, four-component synthesis of 2,2-dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione by condensation of phthalic anhydride, hydrazinium hydroxide, aromatic aldehydes, and dimedone catalyzed by Ce(SO(4))(2)center dot 4H(2)O as an ecofriendly catalyst with high catalytic activity and reusability at 125 degrees C under solvent-free conditions is reported. The reaction proceeds to completion within 5-10 min in 71-95% yield. To the best of our knowledge, this new procedure provides the first example of an efficient synthetic method for 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione via a four-component reaction.

• 出版日期2011-1-26