Aminoalkylations of esters, sulfones, sulfoxides, alkylated pyridines, and nitriles with in situ generated iminium ions

作者：Katritzky Alan R^*; Idzik Krzysztof R; Abdel Fattah Ashraf A A; Soloducho Jadwiga; Steel Peter J

来源：Synthesis, 2006, (20): 3377-3388.

DOI：10.1055/s-2006-949463

• benzotriazoles
• beta-amino esters
• beta-aminoalkyl sulfones
• pyridines
• beta-aminoalkyl cyanides

N-(alpha-Aminoalkyl)benzotriazoles, prepared from a variety of aldehydes and secondary amines, react with diverse ester enolates, sulfones, a sulfoxide, alkylated pyridines, and nitriles to provide novel access to beta-amino carboxylic esters (55-80% yield), beta-aminoalkyl sulfones (42-88% yield), beta-aminoalkyl sulfoxides (20-32% yield), alpha- and gamma-(beta-aminoalkyl)pyridines (69-90% yield), and beta-aminoalkyl cyanides (10-97% yield), respectively.

• 出版日期2006-10-17