科研之友
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摘要
We report a highly diastereoselective synthesis of 1,3-disubstituted tetralin derivatives via Lewis acid catalyzed benzylic C(sp(3))-H bond functionalization. The employment of Hf(OTf)(4) as an acid catalyst was crucial in the reaction, and corresponding tetralins were obtained in good chemical yields with high to excellent diastereo-selectivities (up to 13.3 : 1 d.r.).
- 出版日期2017-4-21
