An efficient, room temperature, oxygen radical anion (O-2(center dot-)) mediated, one-pot, and multicomponent synthesis of spirooxindoles

作者：Gajaganti Somaiah; Bajpai Shivam; Srivastava Vandana; Singh Sundaram

来源：Canadian Journal of Chemistry, 2017, 95(12): 1296-1302.

DOI：10.1139/cjc-2017-0432

<jats:p> The present report highlights an efficient use of oxygen radical anion to promote a room temperature multi-component synthesis of spirooxindoles (4a–4l) under mild reaction conditions. The potassium superoxide (KO<jats:sub>2</jats:sub>) and tetraethylammonium bromide (TEAB) combination generate the oxygen radical anion in situ to promote this transformation. This method offers a sustainable and direct access to the biologically important spirooxindole derivatives in good to excellent yields. </jats:p>

• 出版日期2017-12
• 单位Indian Institute of Technology