Dietary NiCl2 causes G(2)/M cell cycle arrest in the broiler's kidney

作者：Guo, Hongrui; Cui, Hengmin^*; Peng, Xi; Fang, Jing; Zuo, Zhicai; Deng, Junliang; Wang, Xun; Wu, Bangyuan; Chen, Kejie; Deng, Jie

来源：Oncotarget, 2015, 6(34): 35964-35977.

DOI：10.18632/oncotarget.5934

• NiCl2
• G(2)/M cell cycle arrest
• mRNA expression
• protein expression
• kidney

Here we showed that dietary NiCl2 in excess of 300 mg/kg caused the G(2)/M cell cycle arrest and the reduction of cell proportion at S phase. The G(2)/M cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-ATM), p53, p-Chk1, p-Chk2, p21 protein expression and ATM, p53, p21, Chk1, Chk2 mRNA expression, and down-regulation of p-cdc25C, cdc2, cyclinB and proliferating cell nuclear antigen (PCNA) protein expression and the cdc25, cdc2, cyclinB, PCNA mRNA expression.

• 出版日期2015-11-3
• 单位四川农业大学