Antinociception Effect and Mechanisms of Campanula Punctata Extract in the Mouse

作者：Park Soo Hyun; Sim Yun Beom; Lim Soon Sung; Kim Jin Kyu; Lee Jin Koo; Suh Hong Won^*

来源：Korean Journal of Physiology and Pharmacology, 2010, 14(5): 285-289.

DOI：10.4196/kjpp.2010.14.5.285

• Campanula punctata
• Anti-nociception
• Inflammatory pain
• alpha(2) adrenoceptor

In the present study, the antinociceptive profiles of Campanula punctata extract were examined in ICR mice The Campanula punctata contain a large dose of saponin Campanula punctata extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests In addition, Campanula punctata extract attenuated the writhing numbers in the acetic acid-induced writhing test Furthermore, the cumulative nociceptive response time for intrathecal (i t) injection of substance P (0 7 mu g) was diminished by Campanula punctata extract Intraperitoneal (i p) pretreatment with yohimbine (alpha(2)-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Campanula punctata extract in the writhing test However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Campanula punctata extract in the writhing test Our results suggest that Campanula punctata extract shows an antinociceptive property in various pain models Furthermore, this antinociceptive effect of Campanula punctata extract may be mediated by alpha(2)-adrenergic receptor, but not opioidergic and serotonergic receptors

• 出版日期2010-10