Alteration of parameters of energy metabolism and ATPase enzymatic system in juvenile common carp (Cyprinus carpio) chronically exposed to tributyltin

作者：Li, Z. -H.^*; Zhong, L. -Q.; Mu, W. -N.; Wu, Y. -H.

来源：Czech Journal of Animal Science, 2016, 61(7): 326-332.

DOI：10.17221/69/2015-CJAS

• organotin
• fish
• physiological indices
• chronic toxicity
• biomarkers

The effect of long-term exposure to tributyltin (TBT) on energy metabolism and adenosine triphosphatase (ATPase) enzymatic system in freshwater teleost was investigated. The impact on the parameters of energy metabolism (the content of glucose (Glu) and lactate (LA), and the activities of hexokinase (HK), pyruvate kinase (PK), and lactate dehydrogenase(LDH)) in the muscle tissue, as well as on the ATP enzymatic system (ATP content, Total-ATPase, Na+-K+-ATPase, and Ca2+-Mg2+-ATPase) in the gill tissue of common carp was evaluated. Fish were exposed to sublethal concentrations of TBT (75, 0.75, and 7.5 mu g/l) for 60 days. Based on the results, long-term exposure to TBT could lead to obvious ATP enzymatic system responses, including the decreased ATP content and Na+-K+-ATPase activity, and the increased activities of Total-ATPase and Ca2+-Mg2+-ATPase. Moreover, the parameters of energy metabolism in muscle were also regulated, such as induced indices of the levels of Glu and LA, and the activities of HK and PK, and inhibited indices of LDH activity. Shortly, the measured physiological responses in fish could provide useful information to better understand the mechanisms of TBT-induced bio-toxicity, and could be used as potential biomarkers for monitoring the TBT pollution in the field.

• 出版日期2016
• 单位中国水产科学研究院长江水产研究所; 华中农业大学; 西南大学