科研之友
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摘要
Agrochemical research, over the last two decades, has resulted in the discovery of chemically novel insecticides, of which steroids-based compounds that mimic the action of hormones have been considered as safe insecticides. In this study, eight steroidal C-17 pyrazolinyl derivatives were resynthesized through molecular hybridization and their insecticidal activities against 4(th) instar larvae of Mythimna separate were evaluated. These results showed that some compounds exhibited significant insecticidal activities and the susceptibility assays were expressed as the median lethal dose (LD50), of which one of the compounds exerted the most potent insecticidal activity (LD50 = 296 mu g g(-1)), comparable to that of the natural product insecticide, celangulatin V (LD50 = 260 mu g g(-1)). This strategy led to a promising candidate for the development of new steroidal insecticidal agents.
- 出版日期2015-2
- 单位西北农林科技大学
