Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors

作者：Harman Benjamin C; Miller Juli P; Nikbakht Neda; Gerstein Rachel; Allman David^*

来源：Blood, 2006, 108(3): 878-885.

DOI：10.1182/blood-2005-11-4545

Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes, including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP(+) CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that IPDCs arise exclusively from early myeloid progenitors and that promiscuous low-level expression of lymphoidassociated genes is a general feature of PDC progenitors among CMPs.

• 出版日期2006-8-1