A Monomer-Micelle Model for the Formation of Simple Taurocholate Micelles

作者：Yang June Wen; Higuchi William I; Chiang Huey Jenn; Liu Chen Lun^*

来源：Journal of the Chinese Chemical Society, 2010, 57(2): 199-204.

• Kinetic dialysis technique
• Critical micelle concentration
• Monomer-micelle model

A kinetic dialysis technique was used to validate a relationship between monomer taurocholate (TC) concentration and total TC concentration in TC solutions containing 0 15 M NaCl and 0.01 M buffer (pH = 7.4) Based on the experimental data and Mukerjee's equations, the number average degree and the weight average degree of TC aggregates were estimated to be nearly the same (similar to 5), indicating that simple TC micelles were the only aggregates. Furthermore, the TC duller concentration was quantified to be negligible According to the validated relationship, aggregation number of 5 for simple TC micelles, and the definition of critical micelle concentration (CMC), a modified monomer-micelle model was used for describing simple TC micelle formation Moreover, the CMC value was estimated to be similar to 6 3 mM, which is consistent with the reported value of similar to 6.0 mM

• 出版日期2010-4
• 单位东华大学