A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones

作者：Xu, Gang^*; Tong, Chaodi; Cui, Sunliang; Dai, Liyan

来源：Organic and Biomolecular Chemistry, 2018, 16(32): 5899-5906.

DOI：10.1039/c8ob01252k

• CASCADE REACTIONS
• TANDEM CATALYSIS
• ACYL CYANAMIDES
• INHIBITORS
• ACCESS

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls including 1,3-diketones and ethyl acetoacetate has been developed for the facile synthesis of quinazolinones. In the presence of AgNO3/K2S2O8, the diketones could be converted to radicals and coupled with N-cyanamide alkenes to undergo a cyclization cascade for accessing quinazolinones. This method features mild reaction conditions, readily available starting materials, and valuable synthetic utility. Moreover, the products could be further transformed into various heterocycles.

• 出版日期2018-8-28
• 单位浙江大学