Amide, cyclohexenone, and cyclohexenone-sordaricin derivatives from the endophytic fungus Xylaria plebeja PSU-G30

作者：Rukachaisirikul Vatcharin^*; Buadam Sathit; Phongpaichit Souwalak; Sakayaroj Jariya

来源：Tetrahedron, 2013, 69(50): 10711-10717.

DOI：10.1016/j.tet.2013.10.063

• Endophytic fungus
• Xylaria plebeja
• Amides
• Cyclohexenone derivatives
• Cyclohexenone-sordaricin derivatives
• Antifungal activity

Six new compounds, two cyclohexenones, named xylariacyclones A (1) and B (2), three cyclohexenone-sordaricin derivatives, named xylarinonericins A-C (3-5), and one amide derivative, named xylariamide (6), together with 11 known compounds were isolated from the broth extract of the endophytic fungus Xylaria plebeja FSU-G30. The structures were elucidated by analyses of NMR spectroscopic data and chemical methods. Compounds 3-5 are novel and unusual sodaricin derivatives with an ester moiety at C-6 of the sordaricin skeleton. In addition, compound 5 has a unique feature with an ester unit instead of an ether group at C-19. They were evaluated for antifungal activity against Candida albicans ATCC90028 and Oyptococcus neoformarts ATCC90113.

• 出版日期2013-12-16