Discovery of Peptoid Ligands for Anti-Aquaporin 4 Antibodies

作者：Raveendra Bindu L; Wu Hao; Baccala Roberto; Reddy M Muralidhar; Schilke Jessica; Bennett Jeffrey L; Theofilopoulos Argyrios N; Kodadek Thomas^*

来源：Chemistry & Biology, 2013, 20(3): 351-359.

DOI：10.1016/j.chembiol.2012.12.009

Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes. Here, we apply recently developed chemical library screening technology to identify a synthetic peptoid that binds anti-AQP4 antibodies in the serum of NMO patients. This finding validates, in a well-defined human disease, that synthetic, unnatural ligands for the antigen-binding site of a disease-linked antibody can be isolated by high-throughput screening.

• 出版日期2013-3-21