Histological evaluation of rat mammary tumours after treatment with retinoic acid analogues - phytol, TTNPB and vitamin D-3 analogue seocalcitol

作者：Liska Jan^*; Ondkova Slavomira; Macejova Dana; Brtko Julius

来源：Biologia, 2011, 66(2): 365-369.

DOI：10.2478/s11756-011-0024-3

• 1-methyl-1-nitrosourea
• phytol
• TTNPB
• seocalcitol
• mammary tumours
• rats

The effects of retinoic acid analogue - phytol (precursor of retinoic X receptors ligand), TTNPB (retinoic acid receptor agonist) and seocalcitol (EB1089, analogue of vitamin D-3) in mammary tumours of Sprague-Dawley rats induced with 1-methyl-1-nitrosourea (MNU) were investigated. Treatment with phytol, TTNPB and seocalcitol may have some protective and therapeutical effects on malignant processes. Treatment with these components in combination of TTNPB and phytol or seocalcitol and phytol inhibited progression of MNU-induced tumours of the rat mammary gland, and also induced decrease of tumour burden and volume in comparison with treated control group. Treatment of rats with the above compounds had no effect on malignity and invasiveness of carcinomas.

• 出版日期2011-4