A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis

作者：Tanaka Atsushi; Youle Richard J^*

来源：Molecular Cell, 2008, 29(4): 409-410.

DOI：10.1016/j.molcel.2008.02.005

DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In a recent issue of Developmental Cell, Cassidy-Stone et al. (2008) identified mdivi-1, a new DRP1 inhibitor that prevents mitochondria division and Bax-mediated mitochondrial outer membrane permeabilization during apoptosis.

• 出版日期2008-2-29