Different Trajectories of Adolescent Alcohol Use: Testing Gene-Environment Interactions

作者：van der Zwaluw Carmen S; Otten Roy^*; Kleinjan Marloes; Engels Rutger C M E

来源：Alcoholism: Clinical and Experimental Research , 2014, 38(3): 704-712.

DOI：10.1111/acer.12291

• Adolescence
• Alcohol
• Gene
• Parenting
• Development

BackgroundTransitions into heavy alcohol use often already take place during adolescence and are likely to be both genetically and environmentally determined. Therefore, in a 6-wave longitudinal study, we examined the effects of DRD2 Taq1A and OPRM1 A118G genotypes and the interaction with parental rule-setting on different groups of adolescent drinkers. %26lt;br%26gt;MethodsGrowth mixture modeling resulted in 3 distinct groups of adolescent drinkers: light drinkers (n=346), moderate drinkers (n=178), and heavy drinkers (n=72). %26lt;br%26gt;ResultsMultinomial regression showed that moderate drinkers carried the OPRM1 G allele and received lower levels of parental rule-setting significantly more often than the light drinking group. No other significant main effects of DRD2, OPRM1, and rule-setting were found. The interaction between OPRM1 genotype and parental rule-setting significantly distinguished the heavy drinkers from the light (p%26lt;0.001) and moderate groups (p=0.055): Particularly, the alcohol use of OPRM1 G allele carriers was affected by parental rule-setting, while AA genotype carriers remained largely unaffected by parental rules. %26lt;br%26gt;ConclusionsFindings showed that different trajectories of adolescent drinking are preceded by a gene-parenting interaction. These results concur with Belsky%26apos;s theory of plasticity (2009), as well as with Shanahan and Hofer%26apos;s typology of a controlling and restricting gene-environment interaction (2005).

• 出版日期2014-3