Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

作者：Chang John T^*; Ciocca Maria L; Kinjyo Ichiko; Palanivel Vikram R; McClurkin Courtney E; De Jong Caitlin S; Mooney Erin C; Kim Jiyeon S; Steinel Natalie C; Oliaro Jane; Yin Catherine C; Florea Bogdan I; Overkleeft Herman S; Berg Leslie J; Russell Sarah M; Koretzky Gary A; Jordan Martha S; Reiner Steven L

来源：Immunity, 2011, 34(4): 492-504.

DOI：10.1016/j.immuni.2011.03.017

Polarized segregation of proteins in T cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells.

• 出版日期2011-4-22