Antipsychotic Effects of Quetiapine in Naturalistic Long Term Follow Up Study

作者：Lee Jung Sun; Ahn Joon Ho; Kim Do Hoon; Kim Jong Jin; Kim Tae Young; Yoo So Young; Lee Dong Geun; Lee Sang Hyuk; Lim Se Won; Lim Weon Jeong; Jung Il Kyung; Jung Hae Kyung; Cho Dong Hwan; Cho In Hee; Kim Chang Yoon^*

来源：Psychiatry Investigation, 2010, 7(2): 128-134.

DOI：10.4306/pi.2010.7.2.128

• Schizophrenia
• Quetiapine
• Naturalistic study
• High-dose

Objective This study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people.
Methods This study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV We stratified the patients into mild [(clinical global impression severity (CGI-S) <4 at baseline)] and severe groups (CGI-S >= 4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I) <= 2, in the severe group and the aggravation rate in the mild group using the last-observation-carried-forward (LOCF) and the Kaplan-Meier method (K-M).
Results During the 24 weeks, 151(18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5 +/- 1.1 at baseline to 2.8 +/- 1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3% (K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9 +/- 245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommended-dose group (the maximum dose was less than 750 mg/d).
Conclusion This study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients. Psychiatry Investig 2010;7:128-134

• 出版日期2010-6