Ultrathin Selective Molecularly Imprinted Polymer Microdots Obtained by Evanescent Wave Photopolymerization

作者：Fuchs Yannick; Linares Ana V; Mayes Andrew G; Haupt Karsten^*; Soppera Olivier

来源：Chemistry of Materials, 2011, 23(16): 3645-3651.

DOI：10.1021/cm2009829

• photopolymerization
• evanescent wave
• molecularly imprinted polymer
• synthetic receptor
• microstructuring
• molecular recognition

The fabrication of ultrathin selective molecularly imprinted polymer (MIP) microdots using polymerization by evanescent waves (PEW) is demonstrated for the first time. A specific prepolymerization mixture exhibiting suitable photosentivity at 405 nm was developed, containing in particular the visible-light photoinitiator bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide. PEW allows for nanometric resolution of the MIP dots in the z-scale. Within a few seconds, it is possible to generate molecularly imprinted microdots with sub-100 nm thickness. The amino acid Z-(L)-phenylalanine was used as model imprinting template, and the fluorescent dansyl-phenylalanine was employed as a fluorescently labeled derivative for the recognition tests. The MIP microdots showed specific molecular recognition for (L)-phenylalanine derivatives and were able to discriminate dansyl-(L)-phenylalanine from dansyl-(D)-phenylalanine.

• 出版日期2011-8-23