Added value of interferon-gamma release assays in screening for tuberculous infection in the Netherlands

作者：Erkens C G M^*; Dinmohamed A G; Kamphorst M; Toumanian S; van Nispen Dobrescu R; Alink M; Oudshoorn N; Mensen M; van den Hof S; Borgdorff M; Verver S

来源：International Journal of Tuberculosis and Lung Disease, 2014, 18(4): 413-420.

DOI：10.5588/ijtld.13.0589

• cost-effectiveness
• public health resources
• latent tuberculous infection
• interferon-gamma release assay

BACKGROUND: Interferon-gamma release assays (IGRAs) are reported to be more specific for the diagnosis of latent tuberculous infection (LTBI) than the tuberculin skin test (TST). The two-step procedure, TST followed by an IGRA, is reported to be cost-effective in high-income countries, but it requires more financial resources.
OBJECTIVE: To assess the added value of IGRA compared to TST alone in the Netherlands.
METHODS: Test results and background data on persons tested with an IGRA were recorded by the Public Municipal Health Services in a web-based database. The number of persons diagnosed with LTBI using different screening algorithms was calculated.
RESULTS: In those tested with an IGRA, at least 60% of persons who would have been diagnosed with LTBI based on TST alone had a negative IGRA. Among those with a TST reaction below the cut-off for the diagnosis of LTBI, 13% had a positive IGRA. For 41% of persons tested with an IGRA after TST, the IGRA influenced whether or not an LTBI diagnosis would be made.
CONCLUSION: With the IGRA as reference standard, a high proportion of persons in low-prevalence settings are treated unnecessarily for LTBI if tested with TST alone, while a small proportion eligible for preventive treatment are missed. Incremental costs of the two-step strategy seem to be balanced by the improved targeting of preventive treatment.

• 出版日期2014-4