A Novel Cancer Nanotheranostics System Based on Quantum Dots Encapsulated by a Polymer-Prodrug with Controlled Release Behaviour

作者：Huang, Hai-Kang; Yan, Jing; Liu, Pei; Zhao, Bi-Yun; Cao, Yi^*; Zhang, Xue-Fei^*

来源：Australian Journal of Chemistry, 2017, 70(12): 1302-1311.

DOI：10.1071/CH17277

• TARGETED CO-DELIVERY
• DRUG-DELIVERY
• THERANOSTIC APPLICATIONS
• IN-VITRO
• CELLULAR UPTAKE
• LIPOIC ACID
• NANOPARTICLES
• CARRIERS
• LIPOSOMES
• TOXICITY

A nanotheranostic system is a new system that combines both diagnosis and treatment of a malignant disease, e.g. cancer, by exploitation of the unusual properties of nano-sized particles. In this project, we have developed a novel nanotheranostic system based on quantum dots (QDs) coated with drug-loaded polymer. We first synthesized a double-group functionalized amphiphilic triblock copolymer and loaded it with the anti-tumour drug paclitaxel (PTX) and lipoic acid (LA) to obtain the prodrug mPEG-block-PCL-(graft-PTX)-block-PLA-(graft-LA) (mPEG: methoxy polyethylene glycol, PLA: poly(norbornene-lactide)s). When exposed to UV light (365 nm), the disulfide bond of LA was broken into two sulfydryls, which could in turn adhere to the surface of CdSe/ZnS QDs to form a nanotheranostic system. This novel system exhibited good controlled drug release behaviour due to the ester linkage between the drug and polymer. By using typical cancer cell lines, we showed that this nanotheranostic system is promising in cancer diagnosis and treatment in vitro.

• 出版日期2017
• 单位湘潭大学