Partial-Volume Effect Correction Improves Quantitative Analysis of F-18-Florbetaben beta-Amyloid PET Scans

作者：Rullmann Michael^*; Dukart Juergen; Hoffmann Karl Titus; Luthardt Julia; Tiepolt Solveig; Patt Marianne; Gertz Hermann Josef; Schroeter Matthias L; Seiby John; Schulz Schaeffer Walter J; Sabri Osama; Barthel Henryk

来源：Journal of Nuclear Medicine, 2016, 57(2): 198-203.

DOI：10.2967/jnumed.115.161893

• partial-volume effect correction
• PET
• positron emission tomography
• beta-amyloid
• florbetaben

Neocortical atrophy reduces PET signal intensity, potentially affecting the diagnostic efficacy of beta-amyloid (AR) brain PET imaging. This study investigated whether partial-volume effect correction (PVEC), adjusting for this atrophy bias, improves the accuracy of F-18-florbetaben A beta PET. Methods: We analyzed F-18-florbetaben PET and MRI data obtained from 3 cohorts. The first was 10 patients with probable Alzheimer disease (AD) and 10 age-matched healthy controls (HCs), the second was 31 subjects who underwent in vivo imaging and postmortem histopathology for A beta plaques, and the third was 5 subjects who underwent PET and MRI at baseline and 1 y later. The imaging data were coregistered and segmented. PVEC was performed using the voxel-based modified Muller-Gartner method (PVELab, SPM8). From the PET data, regional and composite SUV ratios (SUVRs) with and without PVEC were obtained. In the MRI data, mesial temporal lobe atrophy was determined by the Scheltens mesial temporal atrophy scale and gray matter volumes by voxel-based morphometry. Results: In cohort 1, PVEC increased the effect on AD-versus-HO discrimination from a Cohen d value of 1.68 to 2.0 for composite SUVRs and from 0.04 to 1.04 for mesial temporal cortex SUVRs. The PVEC-related increase in mesial temporal cortex SUVR correlated with the Scheltens score (r = 0.84, P < 0.001), and that of composite SUVR correlated with the composite gray matter volume (r = -0.75, P < 0.001). In cohort 2, PVEC increased the correlation coefficient between mesial temporal cortex SUVR and histopathology score for A beta plaque load from 0.28 (P = 0.09) to 0.37 (P = 0.03). In cohort 3, PVEC did not affect the composite SUVR dynamics over time for the A beta-negative subject. This finding was in contrast to the 4 A beta-positive subjects, in 2 of whom PVEC changed the composite SUVR dynamics. Conclusion: The influence of PVEC on F-18-florbetaben PET data is associated with the degree of brain atrophy. Thus, PVEC increases the ability of F-18-florbetaben PET to discriminate between AD patients and HCs, to detect An plaques in the atrophic mesial temporal cortex, and potentially to evaluate changes in brain Ap load over time. As such, the use of PVEC should be considered for quantitative F-18-florbetaben PET scans, especially in assessing patients with brain atrophy.

• 出版日期2016-2