Aluminum exposure for 60 days at an equivalent human dietary level promotes peripheral dysfunction in rats

作者：Martinez Caroline Silveira; Vera Gema; Uranga Ocio Jose Antonio; Pecanha Franck Maciel; Vassallo Dalton Valentim; Miguel Marta; Wiggers Giulia Alessandra^*

来源：Journal of Inorganic Biochemistry, 2018, 181: 169-176.

DOI：10.1016/j.jinorgbio.2017.08.011

• Metal
• Peripheral neuropathy
• Oxidative stress
• Inflammation

Aluminum (Al) is a neurotoxic associated with a number of chronic human diseases. We investigated the effects of Al exposure at doses similar to human dietary levels and at a high level exposure to AI on the peripheral nervous system. Wistar male rats were divided into two major groups and received orally: 1) First group Low level - rats were subdivided and treated for 60 days: a) Control received ultrapure water; b) AlCl3 received Al at 8.3 mg/kg body weight (bw) for 60 days; and 2) Second group - High level - rats were subdivided and treated for 42 days: C) Control - received ultrapure water through oral gavage; d) AlCl3 received Al at 100 mg/kg bw for 42 days. Von Frey hair test, plantar test, the presence of catalepsy and the spontaneous motor activity were investigated. Reactive oxygen species, lipid peroxidation and total antioxidant capacity, immunohistochemistry to investigate the nerve inflammation and, the specific presence of Al in the sciatic nerve fibers were investigated. Al exposure at a representative human dietary level promotes the development of mechanical allodynia, catalepsy, increased inflammation in the sciatic nerve, systemic oxidative stress and, is able to be retained in the sciatic nerve. The effects of low-dose Al were similar to those found in rats exposed to Al at a dose much higher (100 mg/kg). Our findings suggest that Al may be considered toxic for the peripheral nervous system, thus inducing peripheral dysfunction.

• 出版日期2018-4