Anticholinergic burden and 1-year mortality among older patients discharged from acute care hospital

作者：Lattanzio Fabrizia; Corica Francesco; Schepisi Roberto; Amantea Diana; Bruno Francesco; Cozza Annalisa; Onder Graziano; Volpato Stefano; Cherubini Antonio; Ruggiero Carmelinda; Maggio Marcello G; Corsonello Andrea^*

来源：Geriatrics and Gerontology International, 2018, 18(5): 705-713.

DOI：10.1111/ggi.13234

• anticholinergic burden
• cognitive impairment
• drugs
• falls
• mortality

AimThe association between anticholinergic burden and mortality is controversial. We aimed to investigate whether the anticholinergic cognitive burden (ACB) score predicts 1-year mortality in older patients discharged from acute care hospitals.
MethodsOur series consisted of 807 hospitalized patients aged 65years. Patients were followed up for 12months after discharge. All-cause mortality was the outcome of the study. The ACB score at discharge (0, 1, 2) and increasing ACB score from admission to discharge (no increase, +1, +2 or more) were calculated and used as exposure variables. Cox proportional hazards models adjusted for potential confounders were used for the analysis. Interactions between the ACB score and cognitive impairment or history of falls were also investigated.
ResultsDuring the follow-up period, 177 out of 807 participants (21.9%) died. After adjusting for potential confounders, a discharge ACB score of 2 (HR 1.69, 95% CI 1.09-2.65) was significantly associated with the outcome, whereas the association between increasing ACB score of +2 or more and mortality was weaker (HR 1.30, 95% CI 0.95-1.92). The interaction between the ACB score at discharge or increasing ACB score and cognitive impairment was statistically significant (P =0.003 and P =0.004, respectively), whereas that between the ACB score and falls was not.
ConclusionsThe ACB score at discharge and, to a lesser extent, an increasing ACB score during hospital stay are associated with an increased risk of 1-year mortality in older patients discharged from hospital. Such an association is stronger among patients with cognitive impairment. Geriatr Gerontol Int 2018; 18: 705-713

• 出版日期2018-5