Development of very large electrode arrays for epiretinal stimulation (VLARS)

作者：Waschkowski Florian; Hesse Stephan; Rieck Anne Christine; Lohmann Tibor; Brockmann Claudia; Laube Thomas; Bornfeld Norbert; Thumann Gabriele; Walter Peter^*; Mokwa Wilfried; Johnen Sandra; Roessler Gernot

来源：BioMedical Engineering Online, 2014, 13(1): 11.

DOI：10.1186/1475-925X-13-11

• Retinal prosthesis
• Artificial vision
• Retinitis pigmentosa
• Blindness
• Rehabilitation
• Vitreoretinal surgery
• Silicon wafer Technology
• Polyimide
• Neurostimulation

Background: Retinal implants have been developed to treat blindness causing retinal degenerations such as Retinitis pigmentosa (RP). The retinal stimulators are covering only a small portion of the retina usually in its center. To restore not only central vision but also a useful visual field retinal stimulators need to cover a larger area of the retina. However, large area retinal stimulators are much more difficult to implant into an eye. Some basic questions concerning this challenge should be answered in a series of experiments. %26lt;br%26gt;Methods: Large area retinal stimulators were fabricated as flexible multielectrode arrays (MEAs) using silicon technology with polyimide as the basic material for the substrate. Electrodes were made of gold covered with reactively sputtered iridium oxide. Several prototype designs were considered and implanted into enucleated porcine eyes. The prototype MEAs were also used as recording devices. %26lt;br%26gt;Results: Large area retinal stimulator MEAs were fabricated with a diameter of 12 mm covering a visual angle of 37.6 degrees in a normal sighted human eye. The structures were flexible enough to be implanted in a folded state through an insertion nozzle. The implants could be positioned onto the retinal surface and fixated here using a retinal tack. Recording of spontaneous activity of retinal neurons was possible in vitro using these devices. %26lt;br%26gt;Conclusions: Large flexible MEAs covering a wider area of the retina as current devices could be fabricated using silicon technology with polyimide as a base material. Principal surgical techniques were established to insert such large devices into an eye and the devices could also be used for recording of retinal neural activity.

• 出版日期2014-2-6