A practical route for synthesizing a PET ligand containing [F-18]fluorobenzene using reaction of diphenyliodonium salt with [F-18]F-

作者：Zhang Ming Rong^*; Kumata Katsushi; Suzuki Kazutoshi

来源：Tetrahedron Letters, 2007, 48(49): 8632-8635.

DOI：10.1016/j.tetlet.2007.10.025

The aim of this study was to develop a practical route for preparing a fluorine-18([F-18]) labelled ligand ([F-18]1) containing [F-18]fluorobenzene ring by employing the reaction of diphenyliodonium salt with [F-18]F-. Diphenyliodonium tosylate (2) was synthesized from tributylphenylstannyl compound (6) with [hydroxy(tosyloxy) iodo] benzene (7). Using this method, [F-18]DAA1106 ([F-18]3a), a positron emission tomography ligand for imaging peripheral-type benzodiazepine receptor, was prepared.

• 出版日期2007-12-3