Association of the independent polymorphisms in CDKN2A with susceptibility of acute lymphoblastic leukemia

作者：Zhou, Xueyan; Liao, Fei; Zhang, Junlong; Qin, Yun; Xu, Heng; Ding, Zhenyu; Zhang, Yan^*; Zhang, Feng^*

来源：Bioscience Reports, 2018, 38(3): BSR20180331.

DOI：10.1042/BSR20180331

• GENOME-WIDE ASSOCIATION
• GENETIC POLYMORPHISMS
• RACIAL-DIFFERENCES
• CHILDHOOD
• VARIANTS
• RISK
• ARID5B
• CEBPE
• IKZF1
• 10Q21.2

Acute lymphoblastic leukemia ( ALL) is the most common cancer in children, and alterations in CDKN2A were considered to play an important role on leukemogenesis. Two single nucleotide polymorphisms ( SNPs) at CDKN2A locus were identified to impact on ALL susceptibility via genome wide association studies, and followed by multiple subsequent replication studies at the specific hits. Here, we conducted a systematic review and meta-analysis to re-evaluate the association of both SNPs ( rs3731217 and rs3731249) with ALL susceptibility by gathering the data from 24 independent studies, totally containing 7922 cases/21503 controls for rs3731217 and 6295 cases/24191 controls for rs3731249. Both SNPs were significantly associated with ALL risk ( odds ratio [ OR] = 0.72 and 2.26 respectively), however, exhibit race-specific pattern. In summary, our meta-analysis indicated that two SNPs at CDKN2A locus are associated with ALL susceptibility independently mainly in Caucasians. Future large-scale studies are required to validate the associations in other ethnicities.

• 出版日期2018-6-27
• 单位四川大学