Gold nanoparticle incorporated polymer/bioactive glass composite for controlled drug delivery application

作者：Jayalekshmi A C^*; Sharma Chandra P

来源：Colloids and Surfaces B: Biointerfaces , 2015, 126: 280-287.

DOI：10.1016/j.colsurfb.2014.12.021

• Composite
• Drug delivery
• Gold nanoparticles
• Chitosan
• Gelatin
• Bioglass

The present study discusses the development of a biodegradable polymer encapsulated-nanogold incorporated-bioactive glass composite (AuPBG) by a low-temperature method. The composite was analyzed by atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG), fluorescence and dissolution analysis. The composite exhibited aggregation behaviour in solid and solution states and exhibited negative zeta potential (-13.3 +/- 1.4 mV). The composite exhibited fast degradation starting from the 5th day onwards in phosphate buffered saline (PBS) for a period of 14 days. The composite showed fluorescence quenching effect at pH 7 and the fluorescence recovered at pH 5. The composite has been found to be suitable for the release of doxorubicin at high rates at acidic pH (similar to 5) which is the intracellular pH of tumour cells. The drug loading ratio is also high and it exhibited a controlled release for a period of 8 days in PBS. The system serves as a promising material for targeted drug delivery applications.

• 出版日期2015-2-1
• 单位河北医科大学