An N-heterocyclic carbene-based nickel catalyst for the Kumada-Tamao-Corriu coupling of aryl bromides and tertiary alkyl Grignard reagents

作者：Ando Shin^*; Mawatari Mai; Matsunaga Hirofumi; Ishizuka Tadao^*

来源：Tetrahedron Letters, 2016, 57(30): 3287-3290.

DOI：10.1016/j.tetlet.2016.06.042

• Nickel
• Grignard reagents
• Coupling reaction
• NHC ligand
• Tertiary nucleophile

In this study, nickel-catalyzed coupling reactions between arylhalides and tert-alkyl Grignard reagents were developed. Our original bicyclic NHC ligands reduced the formation of isomerized products, and we found that NMP as a co-solvent suppressed the reduction process. Under the optimal conditions we developed, the catalyst loading was lowered to 0.5 mol %, and catalyst loading using ortho-substituted aryl bromides was also applicable at the level of 2.0 mol %.

• 出版日期2016-7-27