Secondary receptor editing in the generation of autoimmunity

作者：Eisenberg Robert A^*

来源：Autoimmunity Reviews, 2012, 11(11): 787-789.

DOI：10.1016/j.autrev.2012.02.004

• Receptor editing
• Autoimmunity
• B cell
• Autoreactivity

Receptor editing is the process that replaces the heavy chain or light chain variable region genes in a B cell immunoglobulin receptor that is already productively rearranged. It is a major mechanism in the bone marrow for maintaining B cell tolerance to autoantigens. We propose that a pathological autoimmune process can use receptor editing to induce the de novo creation and activation of B cells with autoreactive receptors in the peripheral immune system.

• 出版日期2012-9