An Ethanol Extract of Artemisia iwayomogi Activates PPAR delta Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle

作者：Cho Si Young^*; Jeong Hyun Woo; Sohn Jong Hee; Seo Dae Bang; Kim Wan Gi; Lee Sang Jun

来源：PLos One, 2012, 7(3): e33815.

DOI：10.1371/journal.pone.0033815

Although Artemisia iwayomogi (AI) has been shown to improve the lipid metabolism, its mode of action is poorly understood. In this study, a 95% ethanol extract of AI (95EEAI) was identified as a potent ligand of peroxisome proliferator-activated receptor delta (PPAR delta) using ligand binding analysis and cell-based reporter assay. In cultured primary human skeletal muscle cells, treatment of 95EEAI increased expression of two important PPAR delta-regulated genes, carnitine palmitoyl-transferase-1 (CPT1) and pyruvate dehydrogenase kinase isozyme 4 (PDK4), and several genes acting in lipid efflux and energy expenditure. Furthermore, 95EEAI stimulated fatty acid oxidation in a PPAR delta-dependent manner. High-fat diet-induced obese mice model further indicated that administration of 95EEAI attenuated diet-induced obesity through the activation of fatty acid oxidation in skeletal muscle. These results suggest that a 95% ethanol extract of AI may have a role as a new functional food material for the prevention and/or treatment of hyperlipidermia and obesity.

• 出版日期2012-3-27