Acute traumatic coagulopathy

作者：Cap Andrew; Hunt Beverley^*

来源：Current Opinion in Critical Care, 2014, 20(6): 638-645.

DOI：10.1097/MCC.0000000000000158

• acute traumatic coagulopathy
• endothelial activation
• fibrinolysis
• hemostatic resuscitation
• hypoperfusion
• microparticles
• platelet dysfunction
• tranexamic acid
• viscoelastic coagulation monitoring

Purpose of review %26lt;br%26gt;Mortality from trauma remains a global public health challenge, with most preventable deaths due to bleeding. The recognition of acute traumatic coagulopathy as a distinct clinical entity characterized by early coagulation dysfunction, arising prior to medical intervention, has revolutionized trauma management over the last decade. The aim of this article is to review our current understanding of acute traumatic coagulopathy. %26lt;br%26gt;Recent findings %26lt;br%26gt;We focus on recent advances in the mechanistic understanding of acute traumatic coagulopathy, particularly the changes in coagulation factors, physiological anticoagulants, endothelial activation, fibrinolysis and platelet dysfunction. Evolving diagnostic and therapeutic approaches are discussed, including viscoelastic coagulation monitoring and the role of tranexamic acid and blood products. %26lt;br%26gt;Summary %26lt;br%26gt;Emphasis is now placed on early prevention, diagnosis, and aggressive initial treatment of coagulopathy and fibrinolysis with haemostatic blood products and tranexamic acid in addition to red cell units in order to reduce bleeding and improve clinical outcomes.

• 出版日期2014-12